Avanafil is a phosphodiesterase type 5 (PDE5) inhibitor characterized by a faster onset and lower side effects than other PDE5 inhibitors. This study aimed at improving avanafil solubility in water by its complexation with β-cyclodextrin. Two methods of preparation of complex were investigated namely, rotavap or kneading techniques. Phase solubility analysis showed that drug and β-cyclodextrin formed complex in ratio of 1:1. The complex prepared by rotavap exhibited significantly higher solubility in water than that prepared by kneading (p<0.05). The prepared complexes were investigated using infrared spectroscopy, differential scanning calorimetry and x-ray powder diffraction. Solid state characterization showed that the use of heat during preparation resulted in formation of a new solid phase with lower crystalline properties. The complex prepared by rotavap had higher extent of dissolution in-vitro than pure avanafil, without any significant change in rate.
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